Broncos cornerback Aqib Talib is tossed aside by Avery Williamson after a skirmish on the Titans sideline involving Harry Douglas, who had hit Chris Harris with a low block on the previous play.
Titans tight end Delanie Walker was ruled out of bounds at the 5 yard line as he stretched for the pylon.
DeMarco Murray scored the Titans only touchdown in the first quarter Sunday. He had 92 of Tennessee's 180 yards on the ground.
Marcus Mariota struggled through a 6 for 20 passing day, but added 38 rushing yards on nine attempts.
Left tackle Taylor Lewan and his line mate Jack Conklin did a solid job against Von Miller and Denver's highly touted pass rush.
Linebacker Sean Spence, who later left the game with an ankle injury, was able to keep needed pressure on Denver QB Trevor Siemian.
Marcus Mariota's streak of eight straight games with at least two TD passes ended, but he did not have any turnovers against the Broncos.
Derrick Henry chipped in 42 yards on 12 rushing attempts for the Titans against the Broncos on Sunday.
The Tennessee Titans picked up their biggest victory in recent memory with their 13-10 triumph over the defending Super Bowl champion Denver Broncos.
Photographer Mike Strasinger captured the game in photos as the Titans improved to 7-6 and remained tied with Houston atop the AFC South.